A Panel of four MicroRNAs accurately differentiates Malignant from Benign Indeterminate Thyroid Lesions on Fine Needle Aspiration
نویسندگان
چکیده
Xavier M. Keutgen, Filippo Filicori, Michael J. Crowley, Yongchun Wang, Theresa Scognamiglio, Rana Hoda, Daniel Buitrago, David Cooper, Martha A. Zeiger, Rasa Zarnegar, Olivier Elemento, Thomas J. Fahey III Division of Endocrine Surgery, Department of Surgery, † Department of Pathology, # Institute for Computational Biomedicine, New York Presbyterian Hospital – Weill Cornell Medical Center, 525 E 68 Street, Room A-1027, New York, NY, 10021
منابع مشابه
Imaging, Diagnosis, Prognosis A Panel of Four miRNAs Accurately Differentiates Malignant from Benign Indeterminate Thyroid Lesions on Fine Needle Aspiration
Purpose: Indeterminate thyroid lesions on fine needle aspiration (FNA) harbor malignancy in about 25%of cases.Hemior total thyroidectomyhas, therefore, been routinely advocated for definitive diagnosis. In this study, we analyzed miRNA expression in indeterminate FNA samples and determined its prognostic effects on final pathologic diagnosis. Experimental Design: A predictive model was derived ...
متن کاملA panel of four miRNAs accurately differentiates malignant from benign indeterminate thyroid lesions on fine needle aspiration.
PURPOSE Indeterminate thyroid lesions on fine needle aspiration (FNA) harbor malignancy in about 25% of cases. Hemi- or total thyroidectomy has, therefore, been routinely advocated for definitive diagnosis. In this study, we analyzed miRNA expression in indeterminate FNA samples and determined its prognostic effects on final pathologic diagnosis. EXPERIMENTAL DESIGN A predictive model was der...
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Background and Objectives: Thyroid gland because of its superficial location is amenable to direct physical examination. Clinical assessment of thyroid lesions by means of physical examination, thyroid scans and ultrasonography is not completely reliable. Fine needle aspiration cytology (FNAC) is the most cost-effective, safe and an initial diagnostic test in the pre-operative evaluation of thy...
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Background: Fine needle aspiration (FNA) is the most important method in the diagnosis of thyroid nodules before surgery. Recently, the efficiency of FNA in thyroid nodule management has been debatable. On the other hand, intraoperative frozen section (FS) has been used to confirm the diagnosis of FNA and select the proper surgical approach. In this regard, the present study aimed to assess the...
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Background: Fine-Needle Aspiration Cytology (FNAC) is used for diagnosis of intraocular, orbital and eyelid lesions. In this study we evaluated the outcome and the accuracy of using this technique in diagnosis of benign or malignant behavior of lesions. Methods: FNAC was performed on 26 specimens obtained from 25 patients with intraocular, orbital and eyelid tumors and the results were compared...
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